Johnny Depp

Donnie Brasco / Joseph D. 'Joe' Pistone

Al Pacino

Benjamin 'Lefty' Ruggiero

Michael Madsen

Dominick 'Sonny Black' Napolitano

Bruno Kirby

Nicholas 'Nicky' Santora

James Russo

Paulie

Anne Heche

Maggie Pistone

Zeljko Ivanek

Tim Curley

Brian Tarantina

Bruno

Rocco Sisto

Richard 'Richie' Gazzo

Zach Grenier

Dr. Berger

Gerry Becker

Agent Dean Blandford FBI

Robert Miano

Alphonse 'Sonny Red' Indelicato

Paul Giamatti

FBI Technician

Gretchen Mol

Sonny's Girlfriend

Tim Blake Nelson

FBI Technician

Walt MacPherson

Sheriff

Ronnie Farer

Annette

Terry Serpico

Strip Club Owner

Tony Lip

Philip 'Philly Lucky' Giaccone

George Angelica

Big Trin