Sophie Nélisse

Gilly Hopkins

Kathy Bates

Maime Trotter

Glenn Close

Nonnie Hopkins

Bill Cobbs

Mr Randolph

Octavia Spencer

Miss Harris

Julia Stiles

Courtney Rutherford Hopkins

Clare Foley

Agnes

Billy Magnussen

Ellis

Zachary Hernandez

W.E.

Sammy Pignalosa

Rajeem

Toby Turner

Ticket Agent

Richard Topol

Principal Evans

Salvatore Rossi

Stevie

Cameron Clifford

Ed

Julee Cerda

Mrs. Hong

Johanna Day

Principal Maynard

Katherine Paterson

Clerk

Frank Oz

Cookie Monster (voice)

Blanca Camacho

Additional Voices (voice)

Gavin Westerlind

Ramirez