Matthew McConaughey

Ron Woodroof

Jennifer Garner

Eve

Jared Leto

Rayon

Denis O'Hare

Dr. Sevard

Steve Zahn

Tucker

Michael O'Neill

Richard Barkley

Dallas Roberts

David Wayne

Griffin Dunne

Dr. Vass

Kevin Rankin

T.J.

Donna DuPlantier

Nurse Frazin

Deneen Tyler

Denise

J.D. Evermore

Clint

Ian Casselberry

Hispanic Orderly

Noelle Wilcox

Kelly

Bradford Cox

Sunny

Rick Espaillat

Michael

Lawrence Turner

Foreman

Lucius Falick

Freddie

James DuMont

Rayon's Father

Jane McNeill

Francine Suskind