


Dr. Malcolm Sayer, a shy research physician, uses an experimental drug to "awaken" the catatonic victims of a rare disease. Leonard is the first patient to receive the controversial treatment. His awakening, filled with awe and enthusiasm, proves a rebirth for Sayer too, as the exuberant patient reveals life's simple but unutterably sweet pleasures to the introverted doctor.

Robert De Niro
Leonard Lowe

Robin Williams
Malcolm Sayer

John Heard
Dr. Kaufman

Julie Kavner
Eleanor Costello

Penelope Ann Miller
Paula

Ruth Nelson
Mrs. Lowe

Max von Sydow
Peter Ingham

Anne Meara
Miriam

Dexter Gordon
Rolando

George Martin
Frank

Alice Drummond
Lucy Fishman

Richard Libertini
Sidney

Laura Esterman
Lolly

Barton Heyman
Bert

Judith Malina
Rose

Mary Alice
Nurse Margaret

Keith Diamond
Anthony

Bradley Whitford
Dr. Tyler

John Christopher Jones
Dr. Sullivan
Mary Catherine Wright
Nurse Beth
Penny Marshall
Steven Zaillian
Released